Analyses of TRIMARAN and TRIGGER.

Trimaran trigger. Determinants of response to inhaled extrafine triple therapy in asthma. TRIGGER high-dose in adults with uncontrolled asthma Asthma Control Questionnaire-7 score 15 prebronchodilator FEV 1 less than 80 predicted history of 1 or more asthma exacerbation who had been receiving ICSlong-acting β 2-agonist for at least 4. TRIMARAN and TRIGGER are two randomised parallel-group double-blind active-controlled studies.

Anna Smith Chiesi Group has announced data from two Phase III studies TRIMARAN and TRIGGER the first studies to evaluate the relative efficacy and safety of extrafine formulation single-inhaler triple therapy compared with extrafine formulation inhaled corticosteroid ICS and long-acting β2 agonist LABA in adults with asthma. Open-label BDPFF 2006 µg two inhalations Keywords. TRIMARAN and TRIGGER were double-blind 52-week studies comparing BDPFFG with BDPFF TRIMARAN medium-dose ICS.

In a pre-specified pooled analysis BDPFFG also decreased the annualized rate of severe exacerbations versus BDPFF by 23 the rate of moderate exacerbations by 12 and moderate plus severe exacerbations by 14. A third treatment group was included in TRIG GER. High dose plus a long-acting β2 agonist.

200 μg BDP and 6 µg FF for 2 weeks then randomly assigned to treatment using an interactive response technology system with. Enrolled patients were initially treated with BDPFF TRIMARAN. The lung function predose FEV 1 coprimary endpoint was met in both studies with a slightly larger effect size in TRIGGER.

Singh D Virchow JC Canonica GW Vele A Kots M Georges G Papi A. High dose plus a long-acting β 2 agonist. Sold in 2008 Trigger has since sailed the globe and is available again as a new adventure beckons for the current owners.

TRIMARAN and TRIGGER were two double-blind Phase III 52-week studies comparing the efficacy and safety of medium-strength 100610 µg. Eligible patients were adults aged 1875 years with uncontrolled asthma a history of one or more exacerbations in the previous year and previously treated with inhaled corticosteroid TRIMARAN. Asthma Pharmacotherapy Long-acting β.